The accessory protein ORF3a, from SARS-CoV-2, plays a critical role in viral infection and pathogenesis.Here, we characterized ORF3a assembly, ion channel activity, subcellular localization, and interactome.At the plasma membrane, ORF3a exists mostly as monomers and dimers, which do not alter the native cell membrane conductance, suggesting that OR
RNA functions through the dynamic formation of complexes with RNA-binding proteins (RBPs) in all clades of life.We determined the RBP repertoire of beating cardiomyocytic HL-1 cells by jointly employing two in vivo proteomic methods, mRNA interactome capture and RBDmap.Together, these yielded 1,148 RBPs, 391 of which are shared with all other avail
The background of this study is to see Avena Sativa (Wild Oats) that the Social Service Special Region of Yogyakarta, which is one of the agencies involved in the handling of social welfare problems in view the demands and peramsalahan social welfare are increasingly complex, the Department of Social Welfare in answering this demand by institutiona
Coronavirus disease 2019 (COVID-19) is a disease caused by infection with the SARS-CoV-2 virus and has represented one of the greatest challenges humanity has faced in recent years.The virus can infect a large number of organs, including the lungs and upper respiratory tract, brain, liver, kidneys, and intestines, among many others.Although the gre
RNA sequencing (RNA-seq) has become an exemplary technology in modern biology and clinical science.Its immense popularity is due in large part to the continuous efforts of the bioinformatics community to develop accurate and scalable computational tools to analyze the enormous amounts of transcriptomic data that it produces.RNA-seq analysis enables